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Symptomatic treatment of: - fever and pain such as flu or other infections - Headache - toothache, except before or after dental interventions - nerve pain - spit - muscle pain - menstrual pain.
Aspirin 400 mg - Ascorbic acid 240 mg - Monosodium - Sodium - Citric acid - sodium carbonate.
Posology and method of use:
Method of use
The effervescent tablets in a glass of water and drink. Treatment should be kept as short as possible and its duration should be adjusted to that of the symptomatology.
This is a medicine, no prolonged use without medical advice, Keep out of reach of children, read the leaflet carefully. Ask your doctor or pharmacist. In case of side effects, contact your doctor.
Gastro - duodenumulceraties.
Pathogen increased tendency to bleeding.
clinical situations with risk of haemorrhage.
Concomitant therapy with anticoagulant drugs (eg, coumarin, heparin).
Asthma or known hypersensitivity to salicylates, cross-reactions with other non-steroidal anti-inflammatory (NSAI) drugs and tartrazine.
Severely impaired renal function.
during pregnancy, especially during the last 3 months.
Hepatic, primarily in case of chronic use of high doses.
Patients suffering from allergies (eg hay fever, neuspolyposis, urticaria) or chronic respiratory infections and patients with hypersensitivity to non-steroidal anti-inflammatory (NSAI ) drugs can be at risk for asthma attacks (called analgetica-intolerantie/analgetica-astma). In these cases, treatment should be interrupted. Known hypersensitivity to NSAI drugs is an absolute contra-indication. In patients with a history of gastrointestinal ulceration or haemorrhage or with other digestive symptoms and also in patients with a history of haemorrhagic disorders, caution is required.
Excretion in hepatic function: since the metabolism of aspirin occurs primarily in the liver, should take taken to be a slow degradation of acetylsalicylic acid (retention). In case of renal impairment caution. In renal insufficiency, the degradation kinetics of salicylic acid in blood plasma are not affected, however, takes the content of salicylic acid-inactive metabolites, mainly to conjugated salicylic acid. Prolonged use of high daily doses is not recommended, such as a possible role of high dose salicylates in the development of chronic renal disease was not excluded with certainty.
Salicylisme: the individual susceptibility is highly diverse. Older persons are more susceptible than young adults. Female patients who become pregnant during treatment with the best stop taking the product. In children under 12 years, in whom a viral influenza illness, influenza B or wind smallpox suspects, one will administer aspirin only if other means fail.
If these disorders to disturbances of consciousness and persistent vomiting would come, may be a sign of Reye syndrome, a rare but life-threatening disease conditions under which unconditional and immediate medical treatment is required. A causal relationship to the ingestion of medications containing aspirin has still not firmly established. In any case it is necessary in this and the aforementioned side-effects of treatment interruption. Consideration should be with the sodium content per effervescent tablet (467 mg) for salt-free / low salt diet in patients with congestive heart failure, arterial hypertension and renal insufficiency. It is recommended not to use aspirin shortly before or shortly after pulling teeth. Caution is also advised in patients who must undergo surgery. Shortly before or shortly after alcohol take an aspirin.
Pregnancy and lactation:
The results of research on the use of aspirin during pregnancy in humans do not allow a damaging effect on the child completely eliminate. In animal teratogenicity was observed at high doses. The use of the product during the first trimester of pregnancy is not recommended. Aspirin can pass into the fetal bloodstream and cause salicylaatintoxicatie therein. ACETYLSALICYLATE not administered during the last 3 months of pregnancy because of its effect on bleeding time, also may prolong labor and product delivery delay and may in the fetus a cause premature closure of the ductus arteriosus.
Salicylates go into the breast milk. Therefore it is not recommended during lactation high doses applied. Ascorbic acid is not detected in breast milk. In female patients who become pregnant during treatment is recommended to stop taking the product.
Stomach complaints, gastro-intestinal bleeding, peptic ulcer, melena and occult blood loss that can lead to anemia ferric private.
Rare are hypersensitivity reactions (attacks of respiratory distress, skin reactions, anaphylactic shock).
Bronchospasm may possibly occur.
Acute renal failure, especially in patients with existing niereninsufficiëntie, or congestive heart failure, liver cirrhosis, nephrotic syndrome, or concomitant treatment with diuretics.
When prolonged administration of high doses, may occur salicylisme. Tinnitus is often the first sign. Furthermore, hard of hearing, fatigue, thirst, hyperventilation, vomiting. The individual susceptibility is highly diverse. Older persons are more susceptible than young adults. When tinnitus is the recommended treatment, may temporarily stop. The uric acid excretion is influenced by which salicylates to 1 to 2 g / day and inhibit tubular secretion of 5 to 6 g / day inhibit tubular resorption.
At high doses of vitamin C can cause diarrhea, in patients which led to stone formation, a link between the intake of high doses of vitamin C and the occurrence of oxalate urolithiase supposed to be.
intoxication is almost only after accidental overdose. In acute intoxication is required hospitalization.
Symptoms of overdose
In mild intoxication: nausea, vomiting, stomach pain, dizziness and tinnitus. Larger overdose: confusion, drowsiness, collapse, convulsions, respiratory depression, anuria and possible haemorrhage.
By central hyperventilation, a reduction of CO 2 and an increase in the pH of the blood. The excretion of urine by alkaline carbonates, which alkalireserve is reduced and compensated by a respiratory alkalosis. The clinical symptoms are: hyperpnoea, dyspnoea and profuse sweating without cyanosis. By increasing the progressive poisoning produces a respiratory acidosis respiratory paralysis.
Metabolic acidosis may finally be caused by the decoupling of oxidative fosforilatie and increased CO 2 production.
Possible lethal dose: 150 ; ACETYLSALICYLATE mg / kg. Adults: acute intoxication by absorption from more than 16 g ACETYLSALICYLATE. Children: ACETYLSALICYLATE from 0.100 g / kg. Children are at risk of intoxication.
Treatment of poisoning
Gastric lavage. Since absorption is often delayed by pylorospasme gastric lavage may be performed, even if some time has elapsed since ingestion.
Children: activated charcoal (20 g/100 ml) in suspension into a 70% sorbitol solution .
money and acid-base monitor electrolyte balance.
Depending on the metabolic state, an infusion of sodium hydrogen carbonate, or sodium lactate solution to be administered. The normalization of the acid-base ratio, the increase alkalireserve, salicylic acid is excreted. Sufficient drinking to avoid dehydration and excretion of salicylates easier. Vitamin K can cause sedation. Special features: diuresetherapie, trisbuffer, hemodialysis, artificial ventilation / muscle relaxation.
Increase of: - the effect of anticoagulants (eg coumarin, heparin) - the risk of gastrointestinal haemorrhage with concomitant treatment with corticosteroids - the effect of oral drug hypoglycemiërende (Sulfonylurea agents) - the side effects of methotrexate - digoxin or barbiturate plasma levels (especially at high doses of aspirin).
Reducing the effect of: - spironolactone - furosemide (and any other loop diuretics) - uricosuric agents - antihypertensive drugs.
The association with other NSAI-drugs, including pyrazolone is not recommended. Alcohol, the toxicity of acetylsalicylic acid in the stomach increases.
|Delivery form||Effervescent tablets|
|Type of product||Medicine|
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