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Adjuvant in the treatment of infections of the neusmucosa, the rhinopharynx and sinuses with permeable ostium.
Prophylaxis of infection in the rhino logical surgery.
The treatment is of short duration (no more than 10 days).
framycetin. sulphate i.e. 7800 - Phenylhydrargyr. Nitra - Natr. citras - Acid. Citric. monohydric. - Natr. chlorid. - Aqua purific. q.s. ad 1 ml.
Unit Dose: - by spraying : mcl ± 140, ± 1090 IU or framycetin - per drop: mcl ± 50 or ± 390 IU framycetin.
Dose and method of use:
The sprays done with the bottle in vertical position.
Adults: 1 or 2 sprays in each nostril, 3 to 4 times a day.
Children over 6 years: 1 spray in each nostril, 3 to 4 times a day.
The microdoseerflacon should not in children under 6 years are used.
Adults: 3 to 5 drops of solution in each nostril, 3 to 4 times a day.
Children: 1 or 2 drops of solution in each nostril, 3 to 4 times a day.
Babies: (up to 2 years): 1 drop of solution in each nostril, 3 to 4 times a day.
The treatment should last no longer than 10 days.
This is a medicine, no prolonged use without medical advice, keep away from children, read the leaflet carefully. Ask your doctor or pharmacist. In case of side effects, contact your doctor.
Individual sensitivity to one of the components of Soframycine, especially for the group of antibiotics aminosiden.
The microdoseervorm not administer to children younger than 6 years.
The concomitant administration of framycetin and other potentially ototoxic or nephrotoxic products should be avoided (see section 'Interactions').
Not use for more than 10 days unless, after clinical re-evaluation.
Caution is advised in elderly and in patients with preexisting renal impairment or hearing impairment.
Pregnancy and lactation:
Soframycine during pregnancy and lactation only be used for nasal use of short duration.
The nasal route of framycetin an allergy to antibiotics of the family aminosiden induce. It is hypersensitivity to cutaneous symptoms (skin eruptions) but exceptional.
Framycetin Although the doses that are administered through the nose, extremely low, we mention below, but the side effects of treatment in higher doses, with aminosiden :
In the literature of the deterioration of hearing and equilibrium organ following administration of aminosiden described.
Elderly patients are susceptible to these effects, and patients with a pre-existing hearing impairment.
Cases of nephrotoxicity with aminosiden were reported. There was an increase in serum urea determined, but usually it was normal again soon or immediately after treatment stop put.
The cases of renal failure, following administration of aminosiden were reported, were usually related to a high dose or a prolonged treatment, pre-existing renal disease, hemodynamic disturbances or association with other nephrotoxic products. The nephrotoxicity may be potentiated by certain drugs (see 'Interactions').
It was shown that the potential nephrotoxicity of cephalosporins and cefaloridine especially in the presence of aminosiden may increase. If this combination is given, it is recommended to monitor renal function.
Elderly are also more exposed to kidney damage.
3.) G ASES of neuromuscular blockade and respiratory paralysis have been reported with administration of aminoglycosides to patients during anesthesia myorelaxantia type of curare had been given.
4.) E r were also effects on the central nervous system and described cases of peripheral neuropathy.
This item is not applicable since the nasal and gastrointestinal absorption of framycetin practically non-existent.
See section 'Adverse reactions'.
The combination with ototoxic or nephrotoxic products are not recommended: other aminosiden, cephalosporins, vancomycin, amphotericin B, polymyxin, cisplatin, loop diuretics (furosemide, ethacrynezuur), curariserende substances ciclosprine.
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