Asaflow is designated in the following cardiovascular diseases:
Treatment: Acute treatment of myocardial infarction, of unstable angina, coronary angioplasty and coronary transplant.
Prevention: - a.) Secondary prevention after myocardial infarction, angina, cerebral ischemic cerebro-vascular accident or other accidents, peripheral vascular pain - b) Primary Prevention: in some high-risk myocardial infarction (severe atherosclerotic family history, diabetes, gout, hypertension, dyslipidemias).
Asaflow 80 mg.
Per Tablet: 80 mg Acidum acetylsalicylicum - Maydis amylum - Acidum methacrylicum et ethylis acrylas polymerisatum 1: 1 dispersio 30 per centum - Propylenglycolum - talcum - Simethicone emulsion (Polymethylsiloxane - Methylcellulosum - Acidum sorbicum) - Aqua purificata.
Asaflow 160 mg.
Per tablet: Acidum acetylsalicylicum 160 ; mg - Maydis amylum - Acidum methacrylicum et ethylis acrylas polymerisatum 1:1 dispersio 30 per centum - Propylenglycolum - talcum - Simethicone emulsion (Polymethylsiloxane - Methylcellulosum - Acidum sorbicum) - Aqua purificata.
Posology and method of use:
There is some doubt that the most appropriate dose and duration in the various indications as happened a number of studies with different doses .
treatment start with an initial dose of 320 to 480 mg Asaflow, followed by 160 to 320 mg Asaflow for several weeks. Then switch to the secondary prevention.
Secondary Prevention: 160 to 320 mg per day Asaflow.
Primary prevention: at risk (eg diabetics): 80 to 320 mg per day Asaflow.
Duration of preventive treatment: unlimited.
Asaflow swallowed without chewing it.
In order to avoid oblivion, it is recommended the agenda, on the back of the blister pressed to follow.
A dose reduction should be considered in cases of renal insufficiency (glomerular filtration between 10 and 50 ml / min. ). Do not use in case of a glomerular filtration below 10 ml / min.
Asaflow is not indicated in children.
This is a drug, no long-term use without medical advice, keep away from children, read the leaflet carefully. Ask your doctor or pharmacist. In case of side effects, contact your doctor.
Allergy in front of salicylates, other non-steroidal anti-inflammatory agents and tartrazine. - Allergy in front of one of the ingredients of the preparation. - Gastro-intestinal ulcer. - Constitutional or acquired haemorrhagic disease. - Clinical conditions with increased risk of haemorrhage. - Severe renal impairment.
Asaflow administered with caution in cases of asthma, history of stomach or darmulcus or haemorrhagic disorders. Closely monitor the patient who presents to the digestive disorders of the therapy. - Any overdose detection in cases of mild or moderate renal insufficiency in the elderly. Asaflow not administered in severe renal insufficiency. - In case of failure, liver function tests checked.
Pregnancy and lactation:
Asaflow is not recommended in pregnant women.
At the end of pregnancy administered, the travails Asaflow prolong labor and delay in fetus a premature closure of the ductus arteriosus cause. The more, the risk of bleeding after delivery increased.
Administration of Asaflow avoid if breastfeeding.
Digestive Disorders: Asaflow leads to less occult gastrointestinal bleeding than regular aspirin tablets or effervescent tablets. Any risk of a gastro-intestinal injury can not be excluded: loss of appetite or abdominal pain, gastro-intestinal ulcer, melena or occult blood loss. - Tinnitus and hypoacousis are unlikely given the low daily dose. - Allergic accidents: vasomotor rhinitis, angioneurotic edema, urticaria, asthma, anaphylactic reactions. - Cross Hypersensitivity to other non steroidal anti-inflammatory drugs. - Hepatotoxicity (increased transaminases). - Extra-digestive haemorrhagic accidents: epistaxis, gingivorragie or increase in blood loss during menstruation, thrombocytopenic purpura. It should be noted that the increase in bleeding time, induced by aspirin, for 4 to 6 days after stopping treatment persists. - Disorders acidobasisch balance (respiratory alkalosis, in case of intoxication: metabolic acidosis). - Acute renal failure in the kidney stoornisssen for existing distribution or reduction of circulating plasma volume. - Nephropathy on analgesics and disturbances in the acid-base balance are unlikely given the low dagdosissen.
Since Asaflow not intended for young children is the occurrence of Reye's syndrome unlikely.
Influence on ability to drive and to use machines:
There are no known effects on ability to drive and use machines use.
Symptoms: vomiting, abdominal pains, cephalea, vertigo, tinnitus, mental confusion, profuse sweating, thirst, hyperventilation with respiratory alkalosis, nausea and diarrhea.
In severe intoxication respiratory depression, metabolic acidosis, stupor and coma.
The toxic doses of aspirin depends on the clinical circumstances. Doses of 10 to 30 g led to the death in adults, but higher doses up to 130 g were taken without fatal outcome. Especially in children and elderly is a severe intoxication fear. In children, the estimated toxic dose of aspirin 150 mg / kg.
In severe accidental poisoning is an urgent treatment in hospital: stomach rinses, administration of activated charcoal, reduce the signs of hypothermia and correction of dehydration and the acido-alkaline imbalance. Perfusies promote the urinary excretion of bicarbonate of salicylates. A exsanguinatietransfusie, peritoneal dialysis, hemodialysis or hemoperfusion may be required to accelerate the elimination of salicylates.
Potentiation of the effect of coumarin anticoagulants, sulfonylureas and of methotrexate. - Competition with non steroidal anti-inflammatory agents by moving their binding sites on proteins and uricosuric agents with inhibitory effects on the transtubulair transport of uric acid. Associate with non steroidal anti-inflammatory drugs is not recommended because of the increased risk for adverse effects. - Increase of the gastric toxicity of acetylsalicylic acid by alcohol. - Reduction of the effect of diuretics and antihypertensives.
Inconsistencies are not known.
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